Luke is a former Australian rules footballer who played for the Western Bulldogs, a team he captained for 2 years.

Debuting in 1994, Luke is regarded as one of the Bulldogs' most successful ruckmen/forwards. In 2001 he took out the Charles Sutton Medal, and continued to stamp his name on the game in the following seasons. The following season, he and Michael Voss were the first players to be awarded the Leigh Matthews Trophy as AFL Players Association MVP. In 2004 he was the Western Bulldogs’ leading goalkicker. In 2005, Luke suffered a season-ending knee injury when he twisted it while playing, and later that year, during the final pre-season training session, he re-injured it, causing him to miss the entire 2006 season. Luke retired at the end of the 2007 AFL season.

Since retiring, Luke has continued his work in the media, which he began during his time on the sidelines while injured. He is seen on Ten’s AFL coverage as well as co-hosting ONE's ANZ Netball Championships alongside Australian Netball legend Liz Ellis. He is also part of Triple M Melbourne’s breakfast show with Eddie McGuire, ‘Hot Breakfast’.

Luke is married to Rebecca and they have three children - Sam, Sienna and Willson.